Histone H3 phosphorylation – A versatile chromatin modification for different occasions
نویسندگان
چکیده
منابع مشابه
Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure
Nucleosomes contain ∼146 bp of DNA wrapped around a histone protein octamer that controls DNA accessibility to transcription and repair complexes. Posttranslational modification (PTM) of histone proteins regulates nucleosome function. To date, only modest changes in nucleosome structure have been directly attributed to histone PTMs. Histone residue H3(T118) is located near the nucleosome dyad a...
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In most eukaryotes, the histone methyltransferase SU(VAR)3-9 and its orthologues play amajor role in the function of centromeric heterochromatin. Although the methyltransferase domain isrequired for the formation of a fully functional centromere, mutations within other regions of the genesuch as the N-terminus also have a strong impact on its in vivo function. To analyze the contrib...
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Histone H3 phosphorylation has been linked to various environmental stress responses and specific chromatin structure. The role of H3 phosphorylation in the osmotic stress response was investigated on the mouse mammary tumor virus (MMTV) promoter in different chromatin configurations. Hormone-dependent transcription from the MMTV promoter is repressed by osmotic stress when the promoter is inte...
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ژورنال
عنوان ژورنال: Biochimie
سال: 2012
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2012.04.018